Anabolic Androgenic Steroids (AAS)

Anti Ageing Systems-Clinical Research into Anti Ageing: ” Testosterone … plays a key role in determining a man’s overall health and well-being. High levels of testosterone mean sexual, physical and mental energy, stamina and vitality. Low levels contribute to fatigue, premature ageing and disease ” 

RICK COLLINS JD "Despite over forty years of use by athletes, many of whom are now well into middle-age, we have yet to hear reports of an epidemic of steroid-related deaths. A review of the medical literature does not support the depiction of a serious health crisis related to anabolic steroids ” 

Author and Leading US authority on Steroids: “From the evidence of studies of anabolic steroid administration, it is not readily apparent, that we can attribute significant adverse health effects to anabolic steroids”

DR.CHARLES YESALIS Editor of Anabolic Steroids in Sports and Exercise“Anabolic steroids should not be a classified substance and they can be used safely.” 

Understanding Anabolic Steroids

The people who are naturally big and those who are naturally small differ in one particular sense: Testosterone levels. The testosterone levels of bigger males are elevated and the testosterone levels of smaller men are moderate. It is a biological fact that woman are attracted to or notice large muscular men. There is a genetic predisposition to favor men who are more sexually productive and the female unconsciously recognize this in the more muscular male. Testosterone is a hormone secreted in the testes in men and in small amounts in the ovaries of woman. The main hormone of females is estrogen and both males and females have quantities of both. Testosterone is an anabolic androgenic steroid. Anabolic refers to the fact that it helps build muscle. Androgenic means that the hormone produces male characteristics. Anabolic steroids encourage the development of muscle tissue and they cause the body to retain nitrogen. The greatest benefit ,in terms of growth achievements , is seen when steroids are used in association with a heavy weight training schedule and with higher protein and calorie intake. Whilst these three factors[ training ; protein ;calories] often produce little results, in isolation, we see a hyper leap when anabolic steroids are introduced into the training and eating equation. Using increased levels of protein whilst on a steroid cycle is a sure way to make measurable advances. Over a 1 year period it is possible to turn a 15 inch neck into a 17 inch neck and arms of 14″ to arms of “17. In terms of weight, during the 1st year, a gain of 20% in body weight is possible , putting a man of 10 stone into the 12 stone category. A man of 5′ 8″ can easily, over time, hold 17stone in weight. It is within the control of the bodybuilder to design his own body whilst on steroids. You can achieve a lean muscular physique or a very heavy and powerful frame. Steroids makes this all possible and turns hard gym effort into rapid muscular growth . Large strength gains are also associated with steroid use.

Side effects and politics
Side effects are largely overstated in steroid use. They have emerged from myth and misunderstanding. The American Medical Association has come out and declared that steroids “should NOT be a classified substance” and that “they can be used safely.” Abuse of any medicine can be harmful but moderate and controlled cycling of anabolic steroids results in no adverse side effects. Steroids have become targeted not because of any cogent evidence of health problems but because of their political influence in sponsored athletic and sports activities. It is a fact that athletes who use anabolic steroids in competitions will always have an advantage over participants who compete without these substances. It is the argument of those who use steroids for bodybuilding purposes that they should be allowed to use steroids as a cosmetic enhancement since they are not participating in sports activities which ban such substances. It is fair comment to say that using steroids in competitions is cheating and should be controlled. It is also fair comment to suggest that steroids for cosmetic enhancement should be allowed. In certain countries, including the UK,this is the case and anabolic steroids are allowed for personal use. The sporting lobby in the USA , however, is a powerful voice and millions of dollars in sponsorships from sports goods corporations is a reason for putting steroids in the firing line.

Technical Steroid Facts
Steroids are either injected intramuscularly or taken orally. When injected the substance directly enters the blood stream while tablets taken orally, reach the liver through the gastrointestinal tract. Here the substance is either completely or partially destroyed or sent into the blood stream in its original form. The steroid is now present in the blood in the form of numerous steroid molecules which, through blood circulation, move around the entire body. Each steroid molecule contains a certain message or certain information which it tries to transmit to specific body cells. The cells designated for this purpose possess various receptor types on their membranes. One of these is the steroid receptor which, for example, is present in large amounts at the muscle cell. The form and size of these steroid receptors match those of the steroid molecules. Receptors and molecule show a high affinity, comparable to a key that fits the right lock. The steroid receptor absorbs the matching molecule while rejecting thousands of other molecules which do not fit in size and shape. The same is also true for the many other receptor types which cannot work with the steroid molecule since they are waiting for different molecules Only when the steroid receptor and the steroid molecule have formed a complex can the molecule transmit its message to the muscle cell. During this process it must be observed that the steroid molecules in the blood stream,to a large extent should have already previously bonded with binding proteins Simplified, this means that usually close to 98% of the steroid molecules in the blood are bonded with binding proteins, while only 2% of the steroid molecules are present in a free and unbonded state. The latter form is also called the active steroid molecules since only these can form the steroid receptor complex. The steroid molecules bonded to SHBG [ sex hormone binding globulin] are called the passive steroid molecules since, at this time and in this condition,they cannot be absorbed by the muscle cell and are therefore ineffective. It should be mentioned that the SHBG bonding behavior of some steroids is slightly different,so that the percentage figures can slightly differ. The formed steroid receptor complex now travels to the cell nucleus where it bonds to certain sequences on the nucleic acid sections of the DNA (desoxy ribonuclean acid) Now a transcription takes place, where a template of the DNA is made. The resulting MRNA (messageger ribonnuclean acid) leaves the cell nucleus and bonds with the RNA in the cytoplasm (liquid cell part) where, through translation an increased protein synthesis takes place. When combined with an intensive weight lifting workout , an increase in the diameter of the muscle cell occurs (muscular hypertrophy) .Although the increased protein synthesis is considered to be the most important effect of steroids on the muscle cell, the steroid molecules also forward other information which is important for atheletes. There is increased evidence that steroids have a high anticatabolic effect. Thus, the rate at which protein in the muscle cell is broken down, is reduced.The steroid molecules occupy the cortisone receptors on the membrane of the muscle cell and block them. Therefore, the cortisone produced by the body, a highly catabolic [reducing] hormone, cannot become effective and the muscle cell does not release protein. Another advantage of steroids is that they increase the phosphocreatine synthesis (CP) in the muscle cell. CP is of crucial importance during the restoration of ATP. ATP is required for all muscle contractions since it is the fuel the muscles needs to enable it to work. ATP is stored in the muscle cell and is changed into ADP (adenosine diphosphate) when needed. This process releases energy, allowing the muscle to contract. To change ADP back to ATP,phosphocreatine (CP) is needed the more CP is needed. The more CP that is available, the faster ADP can be reconverted and the more ATP is thus available to the muscle. In practice, this means that the muscle becomes stronger but not larger. For those who have tried the steroid oxandrolone you will have noticed that this compound, for the most part results in a strength gain . This is made possible since oxandrolone highly increases the phosphocreatine synthesis in the muscle cell. Another factor which benefits the atheletes is that the steroids store more carbohydrates in the muscle cell in the form of glycogen. This process together with a higher liquid retention which takes place simultaneously, results in a higher muscle volume, improved endurance, and more strength. Steroids also reduce the release of endogenouis insulin since the steroids allow the muscle cell to absorb nutrients [ carbohydrates in the form of glucose and protein in the form of amino acids] by depending less on the insulin. This helps the athlete in lowering the body fat content and hardening the muscle since insulin, in addition to being a highly anabolic hormone, also converts glucose into glycerol and then triglyceride, thus stimulating the growth of the fat cells. Those of you who have already taken steroids know that during training, a considerably improved pump effect in the respective muscles takes place, which by insiders is called ‘steroid pump’. The reason for this is that steroids increase the blood volume and the amount of red blood cells in the body. The muscle has a larger appearance and becomes more vascular. In addition to these advantages the increased blood flow calls for a greater transport of nutrients to the muscle cells In particular, the highly androgenic steroids such as Dianabol ,testosterone and most of all Anadrol, cause a significant increase in the blood blood volume which sometimes results in an extreme pump during workouts. The improved oxygen supply which results at the same time is often turned into an advantage by medium and long distance runners. After the steroid receptor complex has done its job in the cell nucleus, the steroid molecule returns to the blood system and can either be reused briefly for the same purpose or changed into a weaker , ineffective molecule, which is then excreted through the urine. Not all steroid molecules in the plasma (fluid portion of the blood) are, after exogenous administration, either directly bound to SHBG or present as free, active molecules. A certain portion can be immediately metabolized and eliminated by the body. Another part, however can be converted into the female sex hormone estrogen. This is an aromatizing process and the term, at first, seems difficult to understand. When taking a closer look at the structure of the male sex hormone testosterone and the female hormone estradiol it is noticed that both structures. The body can easily make the necessary structural changes on the molecule by using certain enzymes. Certain steroid molecules, like parts of endogenous and exogenous testosterone, convert into dihydrotestosterone (DHT). Although DHT shows a higher affinity to the receptors of the muscle cell than testosterone does – leading some experts to believe that DHT is more effective than testosterone – it also has a higher boding potential with the receptors of sebaceous glands and hair follicles. It is interesting to note that DHT cannot be converted into estrogen. In the end, all these molecules are excreted as urine. 

DISCLAIMER:

By visiting this site you have stated you are 18 years old or older and are fully aware of the risks associated with taking anabolic steroids or other pharmaceuticals.

All material on this website is provided for your information only and may not be construed as medical advice or instruction. No action or inaction should be taken based solely on the contents of this information; instead, readers should consult appropriate health professionals on any matter relating to their health and well-being.

The information and opinions expressed here are believed to be accurate, based on the best judgement available to the author, and readers who fail to consult with appropriate health authorities assume the risk of any injuries. In addition, the information and opinions expressed here do not necessarily reflect the views of every contributor and we acknowledge the occasional differences in opinion and welcomes the exchange of different viewpoints. The publisher is not responsible for errors or omissions. 


Anabolic Steroid Side Effect Management Table 
By Nelson Vergel

Anabolic steroid (and testosterone) side effects management table courtesy of Nelson Vergel and Michael Mooney (excerpt from the book “Built to Survive“)

 Problem

 Solution and Comments  

 Acne/oily skin

Caused by testosterone and oxymetholone, less by nandrolone, generally not caused by oxandrolone or stanozolol in men, but may cause problems for women.

  • Accutane – a powerful prescription item – 40 mg/day for one week sometimes stops acne if started at the first sign or as directed by your doctor. Accutane is potentially highly liver toxic.
  • Sporanox – Effective for some acne-like eruptions that are caused by fungi. Some doctors also prescribe antibiotics, like tetracycline, for acne with good results.
  • Anti-bacterial soaps - Use a scrubbing brush and wash twice a day, especially after sweating during a workout.
  • UV light or sunlight with moderation.           

 Hair loss

Caused by too much testosterone, and by oxymetholone. Rarely seen with nandrolone, oxandrolone or stanozolol, but they may cause problems for women.

  • Proxiphen salve and NANO shampoo/NANO conditioner – These and other hair loss products are formulated by Dr. Peter Proctor (713-960-1616).
  • Nizoral shampoo– Available by prescription and over-the counter as a lower dose product.
  • Rogaine – Available by prescription.
  • Propecia (finesteride) – Available by prescription. A few males experience decreased erections with finesteride, though (visit www.medibolics.com)

 Increased sex drive

Caused by testosterone and oxymetholone more than other steroids.

  • A problem? Sex drive can decrease in HIV. Sex drive is part of quality-of-life. This is not necessarily a bad side effect. Enjoy it.

 Impotence during a steroid cycle

Rarely caused by testosterone, much more by other steroids. This happens more with steroids other than testosterone because they do not support healthy sexual function in the same way that testosterone does. That is why we recommend that all steroid cycles be built on a testosterone foundation.

  • Viagra, Cialis, Levitra – Available by prescription; enables robust erections. Take an allergy medication and ibuoprofen with it to minimize sinus congestion and headaches.
  • Yohimbine (Yocon) – Available by prescription; increases sex organ sensitivity. Can increase heart rate and blood pressure
  • Muse - Available by prescription; pellet inserted into the urethra to produce erection.
  • Trimix – Available by prescription. The best and cheapest formula for injection into the penis for lasting erections. Visit www.apsmeds.com
  • Caverject - Available by prescription. An injection into the penis that produces an erection that can last 1 to 2 hours. Be careful with injecting too much since it can produce dangerously ling erections that need to be treated in emergency rooms! Follow instructions from your urologist.
  • Papaverine – An older injectable medication, less expensive than Caverject.
  • Wellbutrin – Prescription at 300 to 450 mg/day; increases dopamine.
  • Human chorionic gonadatropin (HCG) – First dose is 5,000 IU, then taken again one week later. Note: If impotence happens while on testosterone, try varying the doses of testosterone. E.g. higher and lower.

 Insomnia

Usually this is caused by dosages that are too high. Find the least amount that gives you a good result.

  • Sleeping medications – e.g. Ambien, Sonata, Restoril
  • Melatonin – 1 to 3 mg before bedtime.
  • Avoid working out too close to bedtime.
  • Limit caffeine, especially after 3 pm.
  • Do not administer oral steroids after 6 pm.
  • Visit houstonbuyersclub.com for a comprehensive sleep formula with tryptophan, melatonin and inositol. Nutrients do not work as well as drugs, but they can help some people.

 Sleep Apnea

  • Have a sleep specialist prescribe a sleep study. Some people may have to wear a C-PAP machine to breathe at night. Visit http://www.sleepapnea.org/ for more information

 Testicular atrophy

Caused by all steroids

  • HCG – One 5,000 unit injection per week for 2 weeks, followed by maintenance of 250 IU twice a week

 Enhanced assertiveness

mostly testosterone, and oxymetholone, but they can all increase
drive depending on dosage.

  • Count until 10 and be aware of your interaction with others.
  • Decrease caffeine.
  • Meditation, yoga, breathe from your belly for a few minutes when over reacting.
  • The steroid dosage may be too high, especially testosterone and oxymetholone.

 High blood pressure/water retention

testosterone, oxymetholone, nandrolone. Sometimes this is caused by elevated hematocrit or water retention and sometimes by steroid doses that are too high. High blood pressure is associated with chronic use of steroids

  • Blood pressure medications - Elevated blood pressure is usually transient and stops within a few weeks of the end of a steroid cycle. However, ongoing or chronic steroid use is associated with high blood pressure. Try ACE or ACE II inhibitors since they seem to have fewer sexual dysfunction related effects.
  • Supplements – Magnesium (600 mg/day); vitamin B6 (100 to 200 mg/day); may help reduce water retention.
  • Water – Drink extra water every day to help flush the kidneys.

 Gynecomastia (male breast development)

Caused by overproduction of estrogen, which can happen when is there is too much testosterone. (Testosterone converts into estrogen.) Oxymetholone use is sometimes involved. Nandrolone is less likely to, while oxandrolone and stanozolol shouldn’t. Growth hormone can also promote it. See the growth hormone section in Anabolic Hormone Guidelines for more information (book: Built to Survive on amazon)

  • Arimidex – Inhibits estrogen production. Available by prescription. 1 mg/day until sensitivity stops, then ½ mg per day. Some people take .5 mg three times a week for maintenance. Ensure that your estradiol is under 20 pg/dl but do not go too low since it is needed for bon, skin and hair health. Some people get it online if doctor does not prescribe. 
  • Nolvadex– Competes with estrogen for receptors. Available by prescription, 10 to 20 mg/day. Not as effective as Arimidex. Use of Nolvadex during a steroid cycle may reduce the net anabolic effect, as it decreases the production of GHIGF-1. Severe cases may require removal of the breast tissue by surgery.
  • DHT cream- Some people have obtained great results by robbing a 10% DHT cream on their nipples. Ask your compounding pharmacy. By prescription only.

 Virilization (body hair growth, deepened voice, clitoral growth in women)

Caused by testosterone, less by oxymetholone and nandrolone, much less by stanozolol. Generally not caused by oxandrolone.

  • Discontinue steroid use or only use steroids that have the lowest androgenic potential, like oxandrolone.
  • We note that GH used with steroids seems to exacerbate body hair growth in males.
  • Proscar– Available by prescription at 1 to 5 mg/day, for men.

 Benign Prostate enlargement

testosterone and oxymetholone. Nandrolone less. Stanozolol and oxandrolone have even less potential to cause this and may not have an effect at all. This is not clear.

  • Proscar – Available by prescription. For men, 1 to 5 mg/day. (Note: Can cause decreased sex drive and erections in some men.)
  • Hytrin, Flomax – Available by prescription.
  • Saw palmetto extract – Very effective for reducing prostate problems, but one study suggests that this herb may reduce the effects of testosterone, too.[ii]
  • Estrogen inhibitors like Arimidex. Estrogen dominance appears to increase prostate growth.[iii] [iv]
  • Check your prostate specific antigen and have a digital rectal exam before starting any steroid program, to detect potential for prostate cancer, especially if you are over 35 or have a family history of prostate problems, and have it checked on a regular basis.

 Polycythemia (Elevated hematocrit, which means there are too many red blood cells)

Caused by testosterone, nandrolone and oxymetholone, much more than oxandrolone or stanozolol.

 Therapeutic phlebotomy means to have a pint or more of blood removed, usually 1 pint per week over several weeks. (1 pint usually will lower hematocrit by about 3 points.) Polycythemia is a compelling reason to avoid using higher steroid doses than are necessary. Taking the lowest effective dose reduces the risk of over-production of hemoglobin (red blood cells).

 

Elevated liver enzymes

Incidence is often exaggerated, but is related to 17-alpha alkylated oral steroids, not oil-based injectable steroids. Note: Injectable stanozolol, which is not approved for human sales in the U.S., is also 17-alpha alkylated.

 

 

  • Standardized silymarin (milk thistle herb) – 160 mg/three times/day.
  • LiverCare – two 640 mg tabs twice per day
  • Evening primrose oil – 1300 mg/three times/day.
  • Lung Tan Xie Gan – Chinese herb formula
  • Alpha lipoic acid – 100 to 300 mg/three times/day.
  • Glycyrrhizinate Forte - Three or more capsules/day, but this may increase blood pressure.
  • N-acetyl cysteine – 600 mg/three times/day
  • Glutamine powder – 4 to 12 grams/three times/day.
  • Omega-3 fatty acids – 6 to 10 capsules per day.
  • With a history of liver problems or Hepatitis C, avoid oral steroids and use only injectable steroids – testosterone or nandrolone.
  • Antioxidant vitamins – Vitamin C – 1,000 to 2,000 mg/three times/day with vitamin E – 400 to 800 IU three times/day.
  • Selenium – 200 mcg twice per day.
  • Alpha lipoic acid – 100 to 300 mg twice per day. We recommend Jarrow brand slow-release alpha lipoic acid.
  • Visit www.houstonbuyersclub.com for a comprehensive formula for liver health

 

[i] Metzger, DL, et al. Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab (1994) 79(2):513-518.

[ii] el-Sheikh, MM, et al. The effect of Permixon (saw palmetto) on androgen receptors. J Acta Obstet Gynecol Scand (1988) 67(5):397-399.

[iii] Suzuki, K, et al. Endocrine environment of benign prostatic hyperplasia: prostate size and volume are correlated with serum estrogen concentration. Scand J Urol Nephrol (1995) 29:65-68.

[iv] Gann, PH, et al. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. The Prostate (1995) 26:40-49.